Accursed Island Campaign

Hello browsers of D20, (and also consequently senior GM's)  
I am planning out a campaign that will begin with the players being shipwrecked on an island along with the boat's former crew and several other various NPC's.  I was wondering if anyone had played through a campaign with a similar setting and if they had any general or specific tips for a beginning GM.  Thanks!
May your victories be absolute and your failures humiliating,
Carl the Chaotic Cleric
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